ACTIVITY OF ASPARTATE AMINOTRANSFERASE IN THE NERVOUS TISSUE OF RATS AFTER SINGLE ADMINISTRATION OF AFOBAZOLE

Matveeva Elena Stanislavovna, Student, Penza State University (40 Krasnaya street, Penza, Russia), moriadora@mail.ru
Baykach Anna Sergeevna, Student, Penza State University (40 Krasnaya street, Penza, Russia), anna.baykach@mail.ru
Grigoreva Olga Mikhailovna, Student, Penza State University (40 Krasnaya street, Penza, Russia), selena3546@mail.ru
Kolesnikova Anastasia Urievna, Student, Penza State University (40 Krasnaya street, Penza, Russia), istudiante@mail.ru
Sharapova Nailya Nailevna, Student, Penza State University (40 Krasnaya street, Penza, Russia), nelya.sharapova.92@mail.ru
Gengin Mikhail Trofimovich, Doctor of biological sciences, professor, sub-department of general biology and biochemistry, Penza State University (40 Krasnaya street, Penza, Russia), gengin07@yandex.ru

577.152.262

Background. The study is aimed to explore possible changes in activity of aspartate aminotransferase in nervous tissues of rats after a single injection of anxiolytic Afobazole.
Materials and methods. Anxiolytic Afobazole ia a common treatment for patients with neuroses and neurosis-like states. Changes in the activity of aspartate aminotransferase in the nervous tissue affects the level of metabolism and energy metabolism of amino acids, affecting the disease development. The enzyme activitу was determined fotometrically in the nervous tissue of rats after 0,5; 4; 24; 72 hours since the injection of Afobazole.
Results. Neuroses and neurosis-like states are associated with changes in the level of the total number of amino acids in nervous tissues. It has been revealed that the Afobazole injection effects the activity of aspartate aminotransferase – an enzyme, regulating the level of amino acids, involved in the metabolic and energetic processes in cells.
Conclusions. Thus, сhanges in the enzyme activity can be one of the mechanisms of regulation of the level of amino acids at the anxiolytic effect of Afobazol.

stress, Afobazol, anxiolytics, aspartate aminotransferase.

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